Thursday, February 25, 2016

Sierra Leone Gov’t to investigate Ebola mutation



By Kemo Cham
[First published on www.politicosl.com] The failure of medical authorities to test for the Ebola virus on the latest Magburaka case may be due to mutation of the virus, a health official has said.
The victim, Marima Jalloh, whose death last week occasioned a setback for the fight against the West African Ebola epidemic, did not present any sign or symptoms associated with the hemorrhagic fever disease when she reported for treatment, said Dr Brima Kargbo, Chief Medical Officer.
“There was no fever when she went to hospital and we all know the cardinal symptom of Ebola is fever,” Dr Kargbo said Saturday at an emergency press conference. He told journalists at the Emergency Operations Center (EOC) that joint teams of Sierra Leonean, WHO and other aid agency officials had been dispatched to four districts where the victim traveled to when she fell ill.
Part of their investigation mandate is to ascertain the source and route of the infection.
Mutation is the changes in the DNA sequence of a gene. This allows the organism like virus, to change form or behaviour.
This may explain the rare appearance of the Magburaka victim who presented none of the known Ebola symptoms, said Dr Kargbo, noting that the 22-year old lady was not even vomiting when she reported at the hospital.
The CMO said genetic sequencing may also be carried out to shed light on this mystery.
Such an investigation will be crucial to restore confidence in the EOC, jointly operated by the Ministry of Health and Sanitation (MoHS) and the Office of National Security (ONS) who have assumed the role of the defunct National Ebola Response Centre (NERC).
The lack of confidence in the health system has already resulted in the reported attack on two quarantine homes and properties of a Paramount Chief in Magburaka by angry youths seeking answers to the lapses on the part of the hospital authorities.
According to reports, when Mariama reported at the outpatient department of the Magburaka Government Hospital, she was treated for mild infections and discharged. She went home only for her condition to deteriorate, leading to her death few days later. The family apparently had no reason to suspect Ebola and so they washed her body the traditional way.
Health authorities said 109 contacts were being quarantined as a result, among them 28 categorised as high risk.As of Saturday January 16, three contacts were also said to be missing.
Meanwhile, the CMO said investigations so far found that the viral strain was the same as the one in the first phase of the epidemic – Zaire Virus – which meant that the latest transmission was linked to the very epidemic the country was declared free from on November 7.
The million-dollar question now is: how did the victim get in contact with the virus? Medical experts had said that the Ebola virus, as it is known today, could only remain alive either in a living host or in a controlled laboratory environment.
The incubation period for the virus – that is the time it takes for it to manifest itself outwardly in a host – is 21 days. If it is not in a living cell it dies within that period.
The idea behind the WHO recommended 42-day countdown to declare a country free of the virus was to ensure that if it existed anywhere outside a host it would have been dead by that time.
The EOC, according to the CMO, was working on four theories: – Firstly, the possibility that the victim might have contracted the virus in one of the places she’d traveled through within the last few days of her life, including Lunsar in Port Loko District, and Bamoi Luma in Kambia District.
Secondly, she might have also contracted it via bush meat consumption – zoonostic transmission, known to be very rare or a third scenario would be through contact with a survivor.
“It may also be a missing chain of transmission,” the CMO said, while cautioning against making hasty conclusion outside scientific realm.
“Right now we leave it very open. We are trying to narrow it down,” he said.
(C) Politico 19/01/16

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